The quarrel with Florence was certain sooner or later, for Florence was growing in strength and riches; she would not for ever be content to let Pisa hold her sea-gate, taking toll of all that passed in and out. It was in 1222 that the first war broke out with the White Lily. Any excuse was good enough; the bone of contention appears to have been a lap-dog belonging to one of the Ambassadors[28]. Pisa was beaten. In 1259, nevertheless, she turned on the Genoese and drove them down the seas. But the death of Frederic in 1250 was the true end of the Ghibelline cause in Italy.
What then did Pisa look like in these the days of her great power and prosperity? She was a city, we may think, of narrow shadowy streets like the Via delle Belle Torri, full of refuse and garbage too, for then, as now in the remoter places, the household slops were simply hurled out of the windows with a mere _guarda_! called from an upper window. And to the horror of less fortunate cities, these streets were full of "Pagans, Turks, Libyans, Parthians, and foul Chaldeans, with their incense, pearls, and jewels." Yet though so good a Guelph as Donizo, the biographer of the great Countess, can express his horror of these "Gentiles," Genoa, too, must have been in much the same case; but then Genoa was Guelph, and Pisa Ghibelline. Yet then, as to-day in that quiet far corner of the city, in a meadow sprinkled with daisies, the great white Duomo stood a silent witness to the splendour of the noblest republic in Tuscany.
But her day was too soon over. In 1254, Florence and Lucca met and defeated her. The Guelphs had won. In Pisa we find the government reformed, elders appointed, a senate, a great council, and Podestà, a Captain of the People. It seemed as though Pisa herself was about to become Guelph, or at any rate to fling out her nobles. But in many a distant colony the nobles ruled, undisturbed by the disaster at home. And then, almost before she had set her house in order, the splendid victory of Monteaperto threw the Guelphs into confusion, and the banners of Pisa once more flew wide and far. But the fatal cause of the Empire was doomed; Manfred fell at Benevento, and Corradino was defeated at Tagliacozzo by Charles of Anjou, who, not content with victory, expelled the Pisan merchants from his ports. There was left to her the sea.