The 2021 La Roue Tourangelle Centre Val de Loire - Tropheé Harmonie Mutuelle was the 19th edition of the La Roue Tourangelle road cycling one day race, which was held on 4 April 2021, starting in the town of Sainte-Maure-de-Touraine and finishing in Tours. It was a category-1.1 event on the 2021 UCI Europe Tour and the third event of the 2021 French Road Cycling Cup.
The race was won in a sprint by Arnaud Démare () ahead of Nacer Bouhanni () and Marc Sarreau ().
Teams
Four UCI WorldTeams, thirteen UCI ProTeams, and five UCI Continental teams made up the twenty-two teams that participated in the race. One team () entered with six riders, two teams ( and ) entered with five, and all others entered with seven. 120 of the 149 riders in the race finished.