The 2021–22 Horizon League men's basketball season began with practices in September 2021 and ended with the 2022 Horizon League men's basketball tournament in March 2022. This was the 42nd season for Horizon League men's basketball.
Head coaches
Coaching changes
On April 13, 2021, IUPUI announced Ball State assistant Matt Crenshaw as the team's new head coach. Previous head coach Byron Rimm II served as the team's head coach for two years while the program's search for a permanent head coach was prolonged by the COVID-19 pandemic.
Preseason
Preseason coaches poll
Preseason All-Horizon League
Preseason Player of the Year: Antoine Davis, Detroit Mercy
Preseason watchlists
Below is a table of notable preseason watch lists.
Rankings
Regular season
Player of the Week awards
Conference matrix
Early season tournaments
The following table summarizes the multiple-team events (MTE) or early season tournaments in which teams from the Horizon League participated.