The 1881 Buffalo Bisons finished the season with a 45–38 record, good for third place in the National League.
A highlight from this season occurred on September 15. In a 12-inning game against Worcester, Buffalo second baseman Davy Force recorded 12 putouts, seven assists, two unassisted double plays, participated in a triple play, and made just one error in 20 chances.
Regular season
Season standings
Record vs. opponents
Roster
Player stats
Batting
Starters by position
Note: Pos = Position; G = Games played; AB = At bats; H = Hits; Avg. = Batting average; HR = Home runs; RBI = Runs batted in
Other batters
Note: G = Games played; AB = At bats; H = Hits; Avg. = Batting average; HR = Home runs; RBI = Runs batted in
Pitching
Starting pitchers
Note: G = Games pitched; IP = Innings pitched; W = Wins; L = Losses; ERA = Earned run average; SO = Strikeouts
Other pitchers
Note: G = Games pitched; IP = Innings pitched; W = Wins; L = Losses; ERA = Earned run average; SO = Strikeouts