The 2021–22 San Antonio Spurs season was the 55th season of the franchise, its 46th in the National Basketball Association (NBA), and its 49th in the San Antonio area. For the first time since 2010–11, long-time point guard Patty Mills is not on the roster, as he signed with the Brooklyn Nets on August 10, 2021. Mills was previously the longest tenured player on the Spurs roster, and the last player from the 2013–14 championship season to remain on the roster. Mills' departure made sixth-year point guard Dejounte Murray the new longest tenured player on the roster.
On April 5, 2022, the Spurs became the 20th and final team to clinch a postseason position, clinching a spot in the elimination round in the play-in tournament for the second consecutive year, qualifying for the second consecutive year in the first stage as the No. 10 seed. However, they lost to the New Orleans Pelicans in the Play-In tournament, eliminating the Spurs from the playoffs for the third consecutive season.
Draft
The Spurs currently carry one first-round pick and one second-round pick.
Roster
Standings
Division
Conference
Schedule
Preseason
|-style="background:#cfc;" | 1 | October 4 | Utah | | Murray, Primo (17) | Jakob Pöltl (10) | Drew Eubanks (4) | AT&T Center10,174 | 1–0 |-style="background:#fcc;" | 2 | October 6 | @ Detroit | | Bryn Forbes (20) | Derrick White (7) | Derrick White (9) | Little Caesars Arena5,423 | 1–1 |-style="background:#fcc;" | 3 | October 8 | Miami | | Keldon Johnson (23) | Drew Eubanks (8) | Dejounte Murray (6) | AT&T Center15,160 | 1–2 |-style="background:#cfc;" | 4 | October 10 | @ Orlando | | Dejounte Murray (18) | Jakob Pöltl (9) | Lonnie Walker (5) | Amway Center12,509 | 2–2 |-style="background:#cfc;" | 5 | October 15 | Houston | | Murray, White (20) | Drew Eubanks (9) | Dejounte Murray (7) | AT&T Center17,676 | 3–2
Regular season
|-style="background:#cfc;" | 1 | October 20 | Orlando | | Devin Vassell (19) | Jakob Pöltl (13) | Dejounte Murray (9) | AT&T Center16,697 | 1–0 |-style="background:#fcc;" | 2 | October 22 | @ Denver | | Keldon Johnson (27) | Dejounte Murray (9) | Derrick White (8) | Ball Arena19,520 | 1–1 |-style="background:#fcc;" | 3 | October 23 | Milwaukee | | Doug McDermott (25) | Dejounte Murray (9) | Derrick White (8) | AT&T Center14,353 | 1–2 |-style="background:#fcc;" | 4 | October 26 | L.A. Lakers | | Jakob Pöltl (27) | Jakob Pöltl (14) | Dejounte Murray (15) | AT&T Center18,354 | 1–3 |-style="background:#fcc;" | 5 | October 28 | @ Dallas | | Dejounte Murray (23) | Jakob Pöltl (13) | Dejounte Murray (8) | American Airlines Center19,228 | 1–4 |-style="background:#cfc;" | 6 | October 30 | @ Milwaukee | | Dejounte Murrary (23) | Keldon Johnson (11) | Dejounte Murray (9) | Fiserv Forum17,341 | 2–4