Roeland J. M. Nolte (Bergh, 1944) is a Dutch chemist, known for his work in the fields of organic chemistry, biochemistry, polymer chemistry, and supramolecular chemistry. He is an emeritus Royal Netherlands of Arts and Sciences professor and an emeritus professor of Organic Chemistry at Radboud University in Nijmegen, The Netherlands. Currently, he holds a special chair, i.e. professor of Molecular Nanotechnology, at this university. Nolte is considered to be one of the pioneers of the field of supramolecular chemistry, which encompasses the design and synthesis of new chemical structures from low molecular weight compounds and biopolymers using so-called non-covalent interactions. He published many studies on supramolecular assembly and biomimetic catalysts, which find applications in the field of nanomaterials and medicine.
Education
Roeland Nolte attended Gymnasium Ruimzicht in Doetinchem, where he graduated in 1963. Thereafter, he studied chemistry at the University of Utrecht, where he received his master's degree in 1969. He continued his studies at the same university, earning a Ph.D. in physical organic chemistry on the synthesis and properties of a new type of polymer in 1973 (supervisor Wiendelt Drenth). After a postdoctoral stage with Nobel laureate Donald J. Cram he joined the Faculty of Science of Utrecht University as an assistant professor.
Career
Nolte started his career as an assistant professor at the University of Utrecht and was promoted to associate professor in 1979. In 1987 he moved to Radboud University in Nijmegen as a Full Professor of Organic Chemistry. Nolte was appointed Adjunct Professor of Supramolecular Chemistry at the Eindhoven University of Technology in 1994. In 2002 he became the first director of the new Institute for Molecules and Materials at Radboud University in Nijmegen, which he remained until his retirement in 2010. In honour of his contributions to science he was awarded a special Royal Netherlands Academy of Arts and Science Professorship in 2003. Nolte retired in 2010 after which he received a special University professorship in Molecular Nanotechnology at Radboud University, which he still holds.
Work
Roeland Nolte's research focuses on supramolecular systems with special properties and functions. These are designed based on the principles of organic chemistry and polymer chemistry, usually by first synthesizing molecular building blocks of different shapes and properties, which are subsequently self-assembled in a second step to form functional nanostructures. Self-assembly takes place by a combination of weak (supramolecular) interactions, such as hydrogen bonding, pi-pi-stacking interactions, van der Waals interactions, and coordination bonds. The designed structures find applications in the fields of materials science and catalysis. Nature is often used as a source of inspiration.
Very early on in his career Nolte discovered the first example of a polymer with a stable helical structure, called atropisomeric polymer, i.e. a polymer which cannot rotate around its main chain carbon atoms. He separated the left-handed and right-handed polymer helices and studied the mechanism of their formation, which was catalyzed by nickel ions and found to take place via a new mechanism, i.e. a polymerization reaction that takes place in a circular fashion around the metal center (merry-go-round mechanism). Later studies on atropisomeric polymers derived from isocyanopeptides revealed that these compounds formed superhelical structures by a supramolecular process of hierarchical self-assembly. Other polyisocyanide derivatives formed hydrogels at very low concentrations, displaying strain stiffening, i.e. they become stronger when a force is applied, a property that previously had only been found in natural materials.
Nolte pioneered the assembly of disc-like molecules, such as porphyrins and phthalocyanines into long supramolecular polymers. Some of these formed super helical structures by a process in which information is transferred stepwise from the building blocks to the polymer chains and subsequently to the helical assembly of polymers. These discs could also be used to generate layers for the alignment of liquid-crystalline molecules by a process of self-assembly and aided assembly.