The Refugio County Courthouse, at 808 Commerce in Refugio, Texas, is a courthouse which was listed on the National Register of Historic Places in 2002.
It was built in 1917 in a Mission style design by architect Atlee B. Ayres. It was greatly enlarged and renovated in 1951 into a Moderne style design by Irving H. Dunbar.
The listing included the courthouse, as a contributing building and also two contributing objects. One is a 1936 historical marker provided by the Texas Highway Department as part of Texas's Centennial celebration.