The 1926 United States Senate election in Pennsylvania was held on November 2, 1926. Incumbent Republican George W. Pepper, who was appointed following the death of Boies Penrose, was defeated for re-nomination by William Scott Vare. Vare won the election, defeating Democratic opponent William Bauchop Wilson. He was not permitted to assume office, however, until an investigation was conducted into possible election fraud and corruption. Vare was ultimately unseated in December 1929 by the Senate, following charges of corruption.
Despite Wilson's loss, this is the last time that the following counties have voted Democratic: Bradford, Cameron, Huntingdon, Lebanon, McKean, Perry, Potter, Snyder, Sullivan, Susquehanna, Tioga, Union, Wayne, and Wyoming.
Republican primary
Candidates
George W. Pepper, incumbent U.S. Senator
Gifford Pinchot, Governor of Pennsylvania and former Chief of the United States Forest Service William Scott Vare, U.S. Representative from Philadelphia
Results
Democratic primary
Candidates
William Bauchop Wilson, former U.S. Secretary of Labor
Results
Prohibition primary
Candidates
Elisha Kent Kane
Gifford Pinchot, Governor of Pennsylvania and former Chief of the United States Forest Service
Results
Socialist primary
Candidates
Cora M. Bixler
Results
Labor primary
Candidates
George W. Pepper, incumbent U.S. Senator
Gifford Pinchot, Governor of Pennsylvania and former Chief of the United States Forest Service William Scott Vare, U.S. Representative from Philadelphia