In December, 1844, Horace Wells, a dentist of Hartford, had a tooth extracted by his own request while under the influence of nitrous oxide; and the following month he came to Boston, and having made his discovery known, an operation at the hospital was undertaken with his assistance, but the patient screamed, and it proved a failure so far as anaesthesia was concerned.

From these facts we readily draw the following conclusions: That the discovery of painless surgery was essentially a practical affair for which only a slight knowledge of chemistry was required; that it was not a discovery made at hap-hazard, but one that necessitated a skilful hand and a clear understanding of the subject; and that the supposition which has sometimes been advanced that Doctor Morton was necessarily indebted to Doctor Jackson for a knowledge of the hypnotic effect of ether is wholly gratuitous.

Cambridge Sketches — Part 149

We will now quote directly from Doctor Warren's lecture on "The Influence of Anaesthesia on the Surgery of the Nineteenth Century," delivered before the American Surgical Association in 1897:

Cambridge Sketches — Part 149

"Morton having acquainted himself by conversation with Mr. Metcalf and Mr. Burnett, both leading druggists, as to purity and qualities of ether, and having also conversed with Mr. Wightman, a philosophical instrument- maker, and with Doctor Jackson as to inhaling apparatus, proceeded to experiment upon himself. After inhaling the purer quality of ether from a handkerchief he awoke to find that he had been insensible for seven or eight minutes.

Cambridge Sketches — Part 149

"The same day a stout, healthy man came to his office suffering from great pain and desiring to have a tooth extracted. Dreading the pain, ho accepted willingly Morton's proposal to use ether, and the tooth was extracted without suffering. Morton reported his success the next day to Jackson, and conversed with him as to the best methods of bringing his discovery to the attention of the medical profession and the public. Jackson pointed out that tooth-pulling was not a sufficient test, as many people claimed to have teeth pulled without pain. It was finally decided that the crucial test lay in a public demonstration in the operating theatre of a hospital in a surgical case."