Anthony James Pawson (18 October 1952 – 7 August 2013) was a British-born Canadian scientist whose research revolutionised the understanding of signal transduction, the molecular mechanisms by which cells respond to external cues, and how they communicate with each other. He identified the phosphotyrosine-binding Src homology 2 (SH2 domain) as the prototypic non-catalytic interaction module. SH2 domains serve as a model for a large family of protein modules that act together to control many aspects of cellular signalling. Since the discovery of SH2 domains, hundreds of different modules have been identified in many proteins.
Biography
Born in Maidstone, England, the son of the sportsman and writer Tony Pawson, and botanist and high-school teacher Hilarie, he was the eldest of three children. He was educated at Winchester College and Clare College, Cambridge, where he received an MA in biochemistry followed by a PhD from King's College London in 1976. From 1976 to 1980 he pursued postdoctoral work at the University of California, Berkeley. From 1981 to 1985, he was Assistant Professor in microbiology at the University of British Columbia.
Pawson was a Distinguished Investigator and former Director of Research at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital and Professor in the Department of Molecular Genetics at the University of Toronto both of which he joined in 1985.
Pawson died on 7 August 2013 of unspecified causes at the age of 60.
Honours and awards
1994 Gairdner Foundation International Award
1994 Fellow of the Royal Society of London and the Royal Society of Canada
1995 Robert L. Noble Prize from the National Cancer Institute of Canada
1998 Pezcoller-AACR International Award for Cancer Research
1998 Heineken Prize for Biochemistry and Biophysics, Royal Netherlands Academy of Arts and Sciences 1998 The Royal Society of Canada Flavelle Medal for meritorious achievement in biological science 2000 J. Allyn Taylor International Prize in Medicine 2004 Louisa Gross Horwitz Prize from Columbia University 2004 Poulsson Medal, the Norwegian Society of Pharmacology and Toxicology 2004 Associate of the National Academy of Sciences (US) 2004 Member of the American Academy of Arts and Sciences 2005 Wolf Prize in Medicine "for his discovery of protein domains essential for mediating protein-protein interactions in cellular signaling pathways, and the insights this research has provided into cancer" 2005 The Royal Medal (The Queen's Medal) from The Royal Society of London 2006 Companion of Honour 2007 Premiers Summit Award 2007 Howard Taylor Ricketts Award from University of Chicago 2008 Kyoto Prize – "Japan's Nobel" for "Proposing and Proving the Concept of Adapter Molecules in the Signal Transduction" 2012 Thomson Reuters Citation Laureates, candidate for Nobel Prize in Medicine "for identification of the phosphotyrosine binding SH2 domain and demonstrating its function in protein-protein interactions" 2013 Annual award of the Canadian National Proteomics Network, thereafter named the CNPN-Tony Pawson Proteomics Award.
References
External links
Anthony Pawson official website at the Samuel Lunenfeld Research Institute
The Official Site of Louisa Gross Horwitz Prize
Online Publications (University of Toronto)