Manuel de la Pezuela y Ceballos, 2nd Marquess of Viluma (8 January 1797, in A Coruña – 20 October 1872, in Madrid) was a Spanish noble and politician who served as Minister of State in 1844.
He was son of Joaquín de la Pezuela, 1st Marquess of Viluma, viceroy of Peru, and of Ángela de Ceballos y Olarria. His younger brother was Juan de la Pezuela y Cevallos. He served as Plenipotentiary Minister in London between 13 February and 2 May 1844.