Phi Sigma Chi () may refer to:
Phi Sigma Chi (sorority), a nearly 100-year old local sorority formed in at Grove City College in Grove City, PA Phi Sigma Chi (fraternity), a 6-chapter multicultural fraternity founded on at the New York City College of Technology, (CUNY) Phi Sigma Chi (Defiance), a local fraternity formed in 1967 at Defiance College in Defiance, OH, which became the Ohio Omicron chapter of Sigma Phi Epsilon () on Phi Sigma Chi (Trine), a local fraternity formed in at Trine University in Angola, IN, which had several fraternal affiliations before becoming the Indiana Theta chapter of Sigma Phi Epsilon () on Phi Sigma Chi (secondary), a dormant high school fraternity founded on in Zanesville, OH, estimated to have chartered 117 chapters