Nottawa Creek (also known as Nottawa River, Nottawaseepe River, and Nottawaseppe River) is a stream in the U.S. state of Michigan that flows into the St. Joseph River at , approximately three miles east of the village of Mendon.
The Nottawa is formed by the outflow of Nottawa Lake in south central Calhoun County. The lake is fed by Nottawa Drain, which along with Goose Pond Drain drains an area to the east of the lake. The Nottawa Creek flows northwest from the lake then arcs to the southwest and flows through the village of Athens before joining the St. Joseph River.
The Nottawa Creek system drains all or portions of the following townships: In Calhoun County Athens Township Burlington Township Clarendon Township Eckford Township Fredonia Township Leroy Township (via Pine Creek) Newton Township Tekonsha Township In Branch County Sherwood Township In Kalamazoo County Climax Township (via Bear Creek) Wakeshma Township (via Bear Creek) In St. Joseph County Leonidas Township