Leighton is an English surname. Notable people with the surname include:
Alexander Leighton (1587–1644), Scottish physician and pamphleteer
Alexander H. Leighton (1908–2007), sociologist and psychiatrist
Amanda Leighton (born 1993), American actress
Baron Leighton of St Mellons, UK peerage title
Bernardo Leighton, Chilean Christian Democrat
Clare Leighton (1898–1989), English-American wood engraver and artist
David Keller Leighton, Sr. (1922–2013), American Episcopalian bishop
Dorothea Leighton (1908–1989), American social psychiatrist and a founder of the field of medical anthropology Edmund Blair Leighton (1853–1922), English painter Edward Leighton (disambiguation), several people F. Thomson Leighton, computer scientist and co-founder of Akamai Technologies Florence Winsome Leighton (born 1948), the birth name of British television presenter Wincey Willis Frederic Leighton, 1st Baron Leighton (1830–1896), English painter and sculptor George N. Leighton (1912–2018), American judge Isabel Leighton (1899-1995), American actress and playwright Jane Leighton, English healthcare activist and television producer Jim Leighton, Scottish footballer Kenneth Leighton (1929–1988), British composer Laura Leighton (born 1968), US actor Michael Leighton (born 1981), Canadian ice hockey goaltender Roland Leighton (1895–1915), British poet and soldier who was killed in the First World War, and Vera Brittain's fiancé Robert Leighton (author) (1858–1934), British author of historical adventure fiction and books about dogs. Father to Clare Leighton (1898–1989) and Roland Leighton (1985–1915) Robert Leighton (bishop) (1611–1684), Scottish preacher, Bishop of Dunblane, Archbishop of Glasgow, & academic Robert Leighton (broadcaster) (1956–2008), English broadcaster Robert Leighton (cartoonist) (born 1960), American writer, puzzle writer and cartoonist Robert Leighton (film editor), British film editor Robert B. Leighton (1919–1997), American physicist Warner E. Leighton, film editor, mainly for Hanna-Barbera