In the years 1570-71 Drake made two voyages to the West Indies, apparently to gain a more precise acquaintance with the seas, the situation, strength, and wealth of the Spanish settlements. In 1572 he sailed with two ships, one of seventy-five tons, the other of twenty-five tons, their united crews mustering only seventy-three men and boys, all volunteers. His object was to capture the now ruined city of Nombre de Dios, situated on the Isthmus of Panama, a few miles east of Porto Bello, then the great repository of all the treasure conveyed from Mexico to Spain. Off this coast of America his little armament was augmented by an English bark, with thirty men on board; so that, deducting those whom it was necessary to leave in charge of the ships, his available force fell short of a hundred men. This handful of bold men attacked the town, which was unwalled, on the night of July 22d, and found their way to the marketplace, where the captain received a severe wound. He concealed his hurt until the public treasury was reached; but before it could be broken open, he became faint from loss of blood, and his disheartened followers abandoned the attempt, and carried him perforce on board ship. Such at least, is the account of the English; there is a Portuguese statement in "Hakluyt's Voyages," vol. iii., p. 525, less favorable both to the daring and success of the assailants.
Failing in this attempt, Drake continued for some time on the coast, visiting Carthagena and other places, and making prize of various ships; and if we wonder at his hardihood in adventuring with such scanty means to remain for months in the midst of an awakened and inveterate enemy, how much more surprising is it that the wealthy, proud, and powerful monarchy of Spain should so neglect the care of its most precious colonies, as to leave them unable to crush so slight a foe! The English appear to have felt perfectly at their ease; they cruised about, formed an intimate alliance with an Indian tribe, named Symerons, the bond of union being a common hatred of the Spaniards, and built a fort on a small island of difficult access, at the mouth of a river, where they remained from September 24 to February 3, 1573. On the latter day, Drake set forth with one portion of his associates, under the conduct of the Symerons, to cross the isthmus. On the fourth day they reached a central hill, where stood a remarkable "goodly and great high tree, in which the Indians had cut and made divers steps to ascend up neere unto the top, where they had also made a convenient bower, wherein ten or twelve men might easily sitt; and from thence wee might without any difficulty plainly see the Atlantic Ocean, whence now wee came, and the South Atlantic (_i.e._, Pacific), so much desired. After our captain had ascended to this bower with the chief Symeron, and having, as it pleased God at that time, by reason of the brize, a very faire day, had seen that sea of which he had heard such golden reports, he besought Almighty God of his goodness to give him life and leave to sayle once in an English ship in that sea." We quote from a tract entitled "Sir Francis Drake Revived," written by some of Drake's companions, corrected, it is said, by himself, and published by his nephew in 1626, which contains a full and interesting account of this adventurous expedition. Drake's present object was to intercept a convoy of treasure on the way from Panama to Nombre de Dios. By this route the treasures of Peru and Chili, as well as Mexico, were brought to Europe, for the passage round Cape Horn was then unknown, and no ship but Magellan's had yet accomplished the passage round the world to Europe. Guided by the Symerons, the English approached Panama, learned that a valuable treasure was expected to pass, and beset the lonely forest road which it had to travel. But the haste of one drunken man gave a premature alarm, in consequence of which the march of the caravan was stopped; and Drake with his party, their golden hopes being thus defeated, forced their way through Venta Cruz, and returned by a shorter route to their encampment, after a toilsome and fruitless journey of three weeks. It was not till April 1st, that the long-desired opportunity presented itself, on which day they took a caravan of mules laden with silver and a small quantity of gold. They carried off part of the spoil, and buried about fifteen tons of silver; but on returning for it, they found that it had been recovered by the Spaniards.