The ézieuxBouthé2021 Engie Open Andrézieux-Bouthéon 42 was a professional women's tennis tournament played on indoor hard courts. It was the eleventh edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Andrézieux-Bouthéon, France between 25 and 31 January 2021.
Singles main-draw entrants
Seeds
1 Rankings are as of 18 January 2021.
Other entrants
The following players received wildcards into the singles main draw: Amandine Hesse Elsa Jacquemot Diane Parry Harmony Tan
The following player received entry using a junior exempt: Victoria Jiménez Kasintseva
The following player received entry using a protected ranking: Lu Jiajing
The following players received entry from the qualifying draw: Susan Bandecchi Gaëlle Desperrier Federica Di Sarra Salma Djoubri Diāna Marcinkēviča Rebecca Šramková Urszula Radwańska Kathinka von Deichmann