The first USS Welles (DD-257) was a in the United States Navy, and transferred to the Royal Navy where she served as HMS Cameron (I05) during World War II.

As USS Welles

Named for Gideon Welles, she was laid down on 13 November 1918 - two days after the signing of the armistice that ended World War I - by the Bethlehem Shipbuilding Corporation's Fore River plant. The ship was launched on 8 May 1919; sponsored by Miss Alma Freeman Welles, the granddaughter of Gideon Welles. Welles was commissioned at the Boston Navy Yard on 2 September 1919.

USS Welles (DD-257)

After her final sea trials off the east coast, Welles joined Squadron 2, Destroyer Force, Pacific Fleet, based at San Diego, California. She operated out of San Diego, "showing the flag" and training, until she was decommissioned there on 15 June 1922. Meanwhile, the destroyer was classified as DD-257 during the fleet-wide assignment of alphanumeric hull numbers on 17 July 1920.

USS Welles (DD-257)

Welles remained at San Diego into the 1930s, as crises multiplied in Europe and the Far East. On 1 September 1939, German forces invaded Poland, triggering World War II. In response to the European conflict, President Franklin D. Roosevelt proclaimed the neutrality of the United States and instructed the Navy to establish a Neutrality Patrol off the eastern seaboard, out of Guantanamo Bay, and at the eastward approaches of the Panama Canal.

USS Welles (DD-257)

To carry out the patrol, the Navy recommissioned 77 destroyers and light minelayers to augment fleet units already at sea that had assumed their patrol stations in September 1939, soon after the outbreak of fighting in Poland. Welles was recommissioned at San Diego on 6 November 1939. She was fitted out at San Diego and then moved to the Mare Island Navy Yard, Vallejo, California, to undergo alterations and a drydocking that started a few days before Christmas and extended into the new year, 1940.

Following the yard work, Welles arrived back at San Diego in company with the destroyer and later departed the area on 5 February, bound for Panama. She transited the Panama Canal on the 16th and stopped at the Submarine Base at Coco Solo on the following day. There, she embarked six enlisted men for transportation to Guantanamo Bay, Cuba, and arrived there on 25 February.

After patrolling the approaches to Guantanamo Bay for nearly two weeks, Welles - transporting 10 enlisted men - sailed for Norfolk, Virginia, with the remainder of her division (Destroyer Division (DesDiv) 67): , , and division flagship on 14 March. Mooring at the navy yard and discharging her passengers on the 17th, the destroyer proceeded to sea on 6 April, bound for the Caribbean.

Arriving at San Juan, Puerto Rico, four days later, Welles departed the same evening. She joined the cruiser on the following morning, and the two ships sailed in company on Neutrality Patrol and conducted exercises until 17 April, when the destroyer returned to San Juan.

Welles patrolled the waters near San Juan from 19 to 23 April before taking part in a battle problem and undergoing her annual military inspection on the 26th. The warship subsequently visited Charlotte Amalie, St. Thomas, Virgin Islands, on 1 May. She remained there for two weeks before returning to San Juan.

Proceeding to sea again on 8 June, Welles conducted exercises en route to Cuban waters and subsequently operated out of Guantanamo Bay over the next few days. During this time, the ship conducted a short-range battle practice. Shifting to Cay Lobos, Great Bahamas, on 20 June, Welles then transported 56 men and one officer from the destroyer to Guantanamo, debarking the men to . Welles then remained at Guantanamo until she sailed for the Canal Zone on 27 July. Anchoring in Limon Bay, Canal Zone, on the 28th, Welles later transited the Panama Canal on 10 August, dropping anchor in Panama Bay on 12 August. She performed target services and conducted exercises and maneuvers with Submarine Division 11 until 16 August, when the destroyer retransmitted the canal, east-bound, and arrived at Coco Solo that day.

Welles sailed for Norfolk on 22 August with the rest of DesDiv 67, proceeded via Guantanamo Bay, and arrived six days later. At that time, Welles and 49 of her sister ships were slated to be transferred to the British government as a result of an agreement reached between President Roosevelt and the British Prime Minister, Winston Churchill.