The 2022 Oeiras Ladies Open was a professional tennis tournament played on outdoor clay courts. It was the second edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Oeiras, Portugal between 4 and 10 April 2022.
Singles main draw entrants
Seeds
1 Rankings are as of 21 March 2022.
Other entrants
The following players received wildcards into the singles main draw: Matilde Jorge Francisca Jorge Ana Filipa Santos Natalija Stevanović
The following player received entry using a junior exempt: Petra Marčinko
The following player received entry as a special exempt: Léolia Jeanjean
The following players received entry from the qualifying draw: Elisabetta Cocciaretto Ingrid Gamarra Martins Katharina Gerlach Justina Mikulskytė Andreea Mitu Ashley Lahey Stefania Rubini Nastasja Schunk
The following players received entry as lucky losers: Alicia Barnett Jéssica Bouzas Maneiro Natalia Vikhlyantseva
Champions
Singles
Elisabetta Cocciaretto def. Viktoriya Tomova, 7–6(7–5), 2–6, 7–5
Doubles
Katarzyna Piter / Kimberley Zimmermann def. Katharina Gerlach / Natalija Stevanović 6–1, 6–1