The 2006 Arizona Wildcats softball team represented the University of Arizona in the 2006 NCAA Division I softball season. The Wildcats were coached by Mike Candrea, who led his twenty-first season. The Wildcats finished with a record of 54–11. They played their home games at Rita Hillenbrand Memorial Stadium and competed in the Pacific-10 Conference, where they finished second with a 15–6 record.
The Wildcats were invited to the 2006 NCAA Division I softball tournament, where they won the Regional and Super Regional and then completed a run through the Women's College World Series to claim their seventh NCAA Women's College World Series Championship.