The 2022 San Marcos Open Aguascalientes was a professional tennis tournament played on clay courts. It was the 1st edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Aguascalientes, Mexico between 18 and 24 April 2022.
Singles main-draw entrants
Seeds
1 Rankings as of April 11, 2022.
Other entrants
The following players received wildcards into the singles main draw: Diego Balderas Rodrigo Pacheco Méndez Shang Juncheng
The following player received entry into the singles main draw as a special exempt: Antoine Bellier
The following players received entry into the singles main draw as alternates: Viktor Durasovic Bernard Tomic
The following players received entry from the qualifying draw: Nicolás Barrientos Elmar Ejupovic Adrián Menéndez Maceiras Shintaro Mochizuki Akira Santillan Matías Zukas
The following player received entry as a lucky loser: Malek Jaziri
Champions
Singles
Marc-Andrea Hüsler def. Juan Pablo Ficovich 6–4, 4–6, 6–3.
Doubles
Nicolás Barrientos / Miguel Ángel Reyes-Varela def. Gonçalo Oliveira / Divij Sharan 7–5, 6–3.