The Environmental Molecular Sciences Laboratory (EMSL, pronounced em-zul) is a Department of Energy, Office of Science facility at Pacific Northwest National Laboratory in Richland, Washington, United States.
Research
EMSL scientists and collaborators perform fundamental research that focuses on the biological, biogeochemical, and physical principles to predict processes occurring at the molecular and genomics-controlled smallest scales to the environmental Earth system changes at the largest scales.
The Functional and Systems Biology Science Area focuses on understanding enzymes and biochemical pathways that connect protein structures and functions to phenotypic responses and interactions within cells, among cells in communities, and between cellular membrane surfaces and their environment for microbes and plants.
The Environmental Transformations and Interactions Science Area focuses on the mechanistic and predictive understanding of the environmental (physiochemical, hydrological, biogeochemical), microbial, plant, and ecological processes in above and belowground ecosystems, the atmosphere, and their interfaces.
The Computing, Analytics, and Modeling Science Area focuses on using state-of-the-art experimental data to develop a predictive understanding of biological and environmental systems through advanced data analytics, visualization, and computational modeling and simulation.
EMSL uses Integrated Research Platforms to uncover critical information for understanding and predicting the molecular functions of biological and ecosystem processes.
Biogeochemical Transformations investigates how molecular interactions at the Earth’s land, water, and air interfaces transform and transport nutrients and contaminants within the environment.
Biomolecular Pathways investigates the translation of genomic information into functional relationships among biomolecules within cells in response to changes in their internal or external environment.
Cell Signaling and Communications reveals dynamic interactions and trafficking of molecular signals within and between cells, populations, and communities to understand complex inter-relationships between organisms in response to their environment.
Terrestrial-Atmospheric Processes investigates molecular transformations, physical processes that control them, and the coupling of terrestrial and atmospheric processes.
Rhizosphere Function investigates interactions between genes and the environment at the molecular level to understand, predict and control plant and ecosystem traits at the systems scale.
Structural Biology gains structural, biochemical, and dynamic information about proteins, protein complexes, and other biomolecules at nanoscale spatial and temporal resolutions to understand function.
Systems Modeling uses computational models of protein structure and function, metabolic modeling, and machine learning approaches to associate genotype with phenotype and to understand biological processes that control nutrient flux, and enable predictive approaches to biodesign and biofuel/bioproduct production.
Operations
EMSL is a user research facility whereby scientists, from around the world, can submit project proposals to access the laboratory’s experts and equipment at no cost. Proposals are screened through a competitive peer-review process to ensure the project is scientifically impactful and relevant to DOE's Office of Biological and Environmental Research mission.
Scientists whose proposals are accepted are referred to as EMSL users. Typical user research projects can last a few months to a few years. EMSL users do not have to stay on-site for the duration of their project and can visit the laboratory when needed. Much of the sample processing and analysis can be handled remotely.
EMSL's user community provides the laboratory’s management team with recommendations for scientific direction and efficient operations through an elected committee of representatives.
History
1986–1997
The idea that would become EMSL began in 1985 with a National Academy of Sciences report titled Opportunities in Chemistry. The report identified scientific challenges relating to energy and the environment that required fundamental research to achieve a solution.