The XVI Venice Challenge Save Cup was a professional tennis tournament played on clay courts. It was the 5th edition of the men's tournament which was part of the 2018 ATP Challenger Tour. It took place in Mestre, Italy between 21 and 27 May 2018.
Singles main-draw entrants
Seeds
1 Rankings as of 14 May 2018.
Other entrants
The following players received wildcards into the singles main draw: Andrea Arnaboldi Filippo Baldi Liam Caruana Gian Marco Moroni
The following players received entry into the singles main draw as special exempts: Luca Vanni Mario Vilella Martínez
The following players received entry from the qualifying draw: Edoardo Eremin Federico Gaio Roberto Marcora Daniel Masur
Champions
Singles
Gianluigi Quinzi def. Gian Marco Moroni 6–2, 6–2.
Doubles
Marin Draganja / Tomislav Draganja def. Romain Arneodo / Danilo Petrović 6–4, 6–7(2–7), [10–2].