Coco Gauff defeated Karolína Muchová in the final, 6–3, 6–4 to win the women's singles tennis title at the 2023 Cincinnati Open. It was her first WTA 1000 title and the first WTA 1000 final appearances for both Gauff and Muchová. Gauff became the youngest champion in Cincinnati history. By reaching the final, Muchová debuted in the top ten of the WTA rankings.
Caroline Garcia was the defending champion, but lost in the second round to Sloane Stephens.
Seeds
The top eight seeds received a bye into the second round.
Draw
Finals
Top half
Section 1
Section 2
Bottom half
Section 3
Section 4
Seeded players
The following are the seeded players. Seedings are based on WTA rankings as of 7 August 2023. Rank and points before are as of 14 August 2023.
The event is not mandatory on the women's side and points from the 2022 tournament are included in the table below only if they counted towards the player's ranking as of 14 August 2023. For other players, the points defending column shows the player's 16th best result.
Points defending will be replaced at the end of the tournament by the highest of (a) the player's points from the 2023 tournament, (b) her 17th best result, or (c) points from her second-highest non-mandatory WTA 1000 event.
† Points from the player's 16th best result (for points defending) or 17th best result (for points earned), in each case as of 14 August 2023. ‡ Points from the player's second-best non-mandatory WTA 1000 event, which are required to be counted in her ranking. § No change in points because points from this tournament did not count as one of the player's 16 best results.