The 2009–10 Clemson Tigers men's basketball team represented Clemson University in the 2009–10 college basketball season. Their head coach was Oliver Purnell. The team played its home games at Littlejohn Coliseum in Clemson, South Carolina and are members of the Atlantic Coast Conference. All games were produced and broadcast locally by the Clemson Tigers Sports Network. The Tigers finished the season 21–11, 9–7 in ACC play. They lost in the first round of the 2010 ACC men's basketball tournament. They received an at-large bid to the 2010 NCAA Division I men's basketball tournament, earning a 9 seed in the Midwest Region, where they defeated Saint Mary's in the first round, but lost the second round to 1 overall seed and AP #1 Kansas

Pre-season

On Wednesday, May 27, guard Terrence Oglesby announced he would forgo his final two seasons at the school to pursue a professional basketball career. Oglesby appeared in 66 games and scored 777 points in his two seasons at Clemson. Previously, Oglesby played for Norway at the International Basketball Federation (FIBA) FIBA Europe Under-20 Championship. In a press release issued by Clemson University, Oglesby indicated that his time spent playing internationally helped fuel his decision to turn pro. Oglesby's departure left an open roster spot which was filled by the commitment of shooting guard Noel Johnson, a former USC commitment.

2009–10 Clemson Tigers men's basketball team

On Tuesday, August 18, ESPN announced that Clemson will serve as one of the host sites for the network's popular basketball series, College GameDay, during the 2009–10 NCAA Division I men's basketball season. Two one-hour shows (11:00 am and 8:00 pm Eastern) will originate from Littlejohn Coliseum on Jan 23, 2010 for the Clemson vs. Duke game. This is Clemson's first appearance on ESPN College GameDay. The series, which is in its sixth season, will make four first-time stops in 2010. Other first-time hosts include Illinois, Kansas State and Washington. The Clemson/Duke game will be one of two ACC tilts featured this season, with the other being North Carolina at Duke on Mar. 6.

2009–10 Clemson Tigers men's basketball team

On Sunday, October 26, 2008, members of the ACC Media were polled and picked Clemson to finish third in the conference behind North Carolina and Duke.

2009–10 Clemson Tigers men's basketball team

Regular season

On December 2, 2009, Illinois came back from a 23-point second-half deficit to upset the No. 18 Tigers, 76–74 at Littlejohn Coliseum. The victory was the biggest comeback win in school history and was also notable as it helped the Big Ten win their first ACC – Big Ten Challenge in eleven tries.

On December 6, 2009, Clemson beat rival South Carolina 72–61, extending their winning streak over the Gamecocks to six games. Carolina leads the overall series, 86–74.

On January 3, 2010, the No. 21 Tigers managed only 12 points in the first half as they lost to No. 7 Duke for the 13th straight time at Cameron Indoor Stadium, 74–53. Clemson had as many fouls as points in the opening period, and their scoring total and shooting percentage (5–30, 17%) were the lowest for a half in Oliver Purnell's seven years as head coach.

On January 13, 2010, the No. 19 Tigers ended a 10-game losing streak to North Carolina by defeating the No. 13 Tar Heels, 83–64 at Littlejohn Arena. It was the second largest margin of victory ever for the Tigers over the Tar Heels. The most being a 20-point 93–73 win in 1976–77, Tree Rollins' senior season. Clemson then followed the win with a 73–70 win at NC State, ending a streak of 13 consecutive losses in the game following a victory over a top 25 team.

On January 23, 2010, ESPN's College GameDay broadcast live from Littlejohn Coliseum for the first time. Afterward, GameDay host Digger Phelps said of the broadcast at Clemson: "It was the best". The crowd was so loud during the broadcast that the production director requested that the crowd keep the noise down when cameras were rolling. The day culminated in a 47–60 loss to Duke, the lowest point total for Duke thus far this season, and the lowest point total of a Clemson team at home since the 2003–04 season, Oliver Purnell's first at Clemson.

Postseason

ACC tournament

Clemson entered the ACC tournament as the No. 6 seed with a 9–7 record in the ACC regular season. The Tigers lost their opening game to No. 11 seed NC State 59–57, dropping their record in the tournament to 16–57 all-time with 43 of their losses coming in the first round. Clemson remains the only original member of the ACC to have never won the tournament.