U.S. Route 29 (US 29) is a north–south United States highway that travels from the Savannah River to Blacksburg, entirely in Upstate South Carolina.
Route description
US 29 enters South Carolina crossing the Savannah River, downstream from Hartwell Dam, and proceeds to travel along the forested eastern edge of Lake Hartwell for , where it meets up with Old US 29. From there, it goes on a northeasterly direction towards Anderson. outside Anderson, US 29 Business takes a left turn and more direct route into the downtown area; while mainline US 29 continues east, with most signage signed "TRUCK" instead of the more usual "BY-PASS" (state maps confirm it is the mainline route). At SC 81, US 29 takes a left turn and follows briefly before taking a right turn at Shockley Ferry Road. Crossing SC 28 Business, the road widens to an undivided four-lane, continuing until reaching River Street (US 76/US 178); where US 29 makes another right turn and then soon left again. US 29 meets back with US 29 Business at Williamston Road. Continuing northeast for another , US 29 makes a junction with US 29/SC 20 Connector to Williamston; the highway briefly divides at junction. With another , US 29 merges with northbound Interstate 85 (exit 34, northbound exit and southbound entrance only).

After traveling in concurrency with Interstate 85, US 29 switches onto Interstate 185 at exit 42 (exit 14B on Interstate 185). After , Interstate 185 ends at Henrydale Avenue; US 29 continues along Mills Avenue, followed by Church Street (staying straight), through downtown Greenville. At North Street and Academy Street (US 123), travelers can connect to Interstate 385; between the two streets is the Bon Secours Wellness Arena. Church street eventually ends onto Wade Hampton Boulevard, which is a divided six-lane highway from Greenville to Greer.

Once after passing through Greer, the highway shrinks to a divided four-lane highway, continuing through Lyman and Wellford. After passing Interstate 85 (exit 66) and Interstate 26 (exit 21), US 29 enters Spartanburg and through one of the busiest commercial areas in the city, centered at Westgate Mall (the highway is widen to six-lanes throughout the commercial area). As US 29 enters the city center area, it takes a left onto Saint John Street, then proceeds to parallel Main Street before rejoining later. At Pine Street (US 176/SC 9), travelers can connect to Interstate 585. US 29 continues in a northeasterly direction into Cowpens, where the highway reduces down to a two-lane through town.

After passing through Cowpens, the road widens again to an undivided 4-lane for before entering into Gaffney. Continuing as a two-lane road through both Gaffney and Blacksburg, it crosses one last time with Interstate 85 (exit 106), before entering North Carolina.
History
From its inception until 1959, US 29 was the main thoroughfare in Upstate South Carolina and connecting regionally with Atlanta and Charlotte. Though still important in the upstate, it now takes a traveler on a more indirect route compared to Interstate 85.
Established in 1927 as an original U.S. Route, it generally traversed the same today as it then when created; from Georgia to North Carolina, via Anderson, Greenville, Greer, Spartanburg, Gaffney, and Blacksburg. The entire route was in concurrency with SC 8.
In 1928, SC 8 was rerouted completely off US 29. In 1935, US 29 was rerouted onto new alignment between Anderson and Greenville. The old routing using Greenville Road onto Old Anderson Road, then east on Pendleton Road and finally Main Street was renumbered as SC 81. The new routing turns at Williamson Road, to Williamston, Pelzer, and Piedmont, before entering Greenville on Grove Road, Allen Street, Pendleton Street, and finally Main Street. The new alignment replaced SC 248 and part of SC 20.
In 1938, US 29 was rerouted from Greenville northward. From using Main Street, to Buncombe Road, to Rutherford Avenue, and to Camp Road into Greer. The new routing follows Main Street to Stone Avenue and finally to Wade Hampton Boulevard.
Between 1943-1946, US 29 was moved onto new road bypassing Greer and Duncan. In 1947, US 29 was given a southeastern bypass of Anderson, creating a business loop through downtown. In 1948, US 29 was rerouted onto Grove Road and Augusta Road, leaving Allen Street and Green Street, in Greenville.





