The Church of Antioch owed its foundation to some believers originally from Cyprus and Cyrene, who had already been much engaged in preaching. Up to this time they had only addressed themselves to the Jews. But in a city where pure Jews--Jews who were proselytes, "people fearing God"--or half-Jewish pagans and pure pagans, lived together, exclusive preaching restricted to a group of houses became impossible. That feeling of religious aristocracy on which the Jews of Jerusalem so much prided themselves did not exist in those large cities, where civilization was altogether of the profane sort, where the scope was greater, and where prejudices were less firmly rooted. The Cypriot and Cyrenian missionaries were then constrained to depart from their rule. They preached to the Jews and to the Greeks indifferently.
The success of the Christian preaching was great. A young, innovating, and ardent Church, full of the future, because it was composed of the most diverse elements, was quickly founded. All the gifts of the Holy Spirit were there poured out, and it was easy to perceive that this new Church, emancipated from the strict Mosaism which erected an insuperable barrier around Jerusalem, would become the second cradle of Christianity. Assuredly, Jerusalem must remain forever the capital of the Christian world; nevertheless, the point of departure of the Church of the Gentiles, the primordial focus of Christian missions, was, in truth, Antioch. It was there that for the first time a Christian church was established, freed from the bonds of Judaism; it was there that the great propaganda of the apostolic age was established; it was there that St. Paul assumed a definite character. Antioch marks the second halting-place of the progress of Christianity, and, in respect of Christian nobility, neither Rome nor Alexandria nor Constantinople can be at all compared with it.
The foundation of Christianity, from this point of view, is the greatest work that the men of the people have ever achieved. Very quickly, without doubt, men and women of the high Roman nobility joined themselves to the Church. At the end of the first century, Flavius Clemens and Flavia Domitilla show us Christianity penetrating almost into the palace of the Cæsars.