The James Hamilton House is a historic home located in Bowie, Prince George's County, Maryland, United States. The home was built in the mid-1870s, and is a -story gable-roofed frame Late Victorian house with Italianate detail. Outbuildings include a board-and-batten meat house contemporary with the house, a garage constructed in the 1950s, and a large concrete block dairy barn to the east of the house, constructed in the 1960s.
The James Hamilton House was listed on the National Register of Historic Places in 1988.