D.565 is a long north–south state road running south from İğneada on the Black Sea to Izmir. The route is broken into two parts by the Sea of Marmara: a long section in East Thrace from İğneada to Tekirdağ and a section in Anatolia from Bandırma to Izmir. The gap is connected by a car ferry operating between the two port cities. The route is mostly a four lane highway except for the first section at its northern end.
In two separate sections, the D.565 runs concurrently with two other state roads in East Thrace: with the D.020 between Poyralı and Pınarhisar and with the D.100 between Lüleburgaz and Büyükkarıştıran.