The following highways are numbered 161:
Canada
New Brunswick Route 161
Prince Edward Island Route 161
Quebec Route 161
Costa Rica
National Route 161
India
National Highway 161
Ireland
R161 road (Ireland)
Japan
Japan National Route 161
United Kingdom
from Beckingham to Goole
B161 road from A114 (Forest Gate) to A112 (near Leyton)
United States
U.S. Highway 161 (former) Alabama State Route 161 Arkansas Highway 161 California State Route 161 Connecticut Route 161 Florida State Road 161 Georgia State Route 161 (former) Illinois Route 161 Indiana State Road 161 Iowa Highway 161 (former) K-161 (Kansas highway) Kentucky Route 161 Louisiana Highway 161 Maine State Route 161 Maryland Route 161 Mississippi Highway 161 Missouri Route 161 Nevada State Route 161 New Jersey Route 161 New Mexico State Road 161 New York State Route 161 North Carolina Highway 161 Ohio State Route 161 Pennsylvania Route 161 (former) South Carolina Highway 161 Tennessee State Route 161 Texas State Highway 161 Texas State Highway Spur 161 Utah State Route 161 Virginia State Route 161 Washington State Route 161 West Virginia Route 161 Wisconsin Highway 161 Wyoming Highway 161 Territories Puerto Rico Highway 161