John Hardy "Johnny" Isakson (December 28, 1944 – December 19, 2021) was an American politician. He was the United States Senator from Georgia from 2005 through 2019. He was a member of the Republican Party. Previously, he represented Georgia's 6th Congressional district in the United States House of Representatives from 1999 to 2005.
In June 2015, Isakson was diagnosed with Parkinson's disease and a kidney tumor.
On August 28, 2019, due his bad health, Isakson announced that he would resign from the Senate officially on December 31, 2019.
Isakson died on December 19, 2021 at his home in Atlanta, Georgia from Parkinson's disease-related problems at the age of 76.