S. maculata may refer to:

Sabatia maculata, a plant endemic to the eastern United States

Saccogaster maculata, a viviparous brotula

Salisia maculata, a herbaceous plant

Sarangesa maculata, an African butterfly

Scapteira maculata, a lizard endemic to northwestern Africa

Scardamia maculata, a geometer moth

Schinia maculata, a flower moth

Scolia maculata, a very large wasp

Selenaria maculata, a moss animal

Setia maculata, a sea snail

Shebania maculata, a snout moth

Sigapatella maculata, a sea snail

Sillago maculata, a coastal marine fish

Siphona maculata, a tachina fly

Skenea maculata, a sea snail

Solariella maculata, a top snail

Spermophora maculata, a cellar spider

Spiloconis maculata, a net-winged insect

Squilla maculata, a mantis shrimp

Stachyris maculata, an Old World babbler

Stagmomantis maculata, a mantis native to the Americas

Stathmopoda maculata, a concealer moth

Statilia maculata, a praying mantis

Stauntonia maculata, a flowering plant

Stellognatha maculata, a flat-faced longhorn

Stomatella maculata, a sea snail

Stratiomys maculata, a soldier fly

Subula maculata, an auger snail

Swanka maculata, a mud turtle

Symbolia maculata, a long-legged fly

Synapta maculata, a sea cucumber

Synaptula maculata, a sea cucumber

Synemon maculata, a diurnal moth

S. maculata