The –MŠKŽ2021–22 season is MŠK Žilina's 114th season in existence and the club's 25th consecutive season in the top flight of Slovak football. In addition to the domestic league, Žilina participated in this season's edition of the Slovak Cup and the UEFA Europa Conference League.
Current squad
As of 4 August 2021
For recent transfers, see List of Slovak football transfers summer 2021.
Out on loan
Reserve team
MŠK Žilina B are the reserve team of MŠK Žilina. They currently play in the second-level football league in Slovakia 2. Liga.