Sheila Sue David is an American chemist who is a professor at the University of California, Davis. Her research uses chemical approaches to understand cellular mechanisms, including DNA repair. She focuses on the repair of damaged DNA bases, which is mediated by base excision repair. She is a Fellow of the American Chemical Society and American Association for the Advancement of Science.
Early life and education
David became interested in DNA as a child, when she explored the laws of Mendelian inheritance by breeding mice in fifth grade. She converted one of the rooms in her house into a science laboratory. She became interested in biochemistry during her undergraduate degree at St. Olaf College, where she discovered structure-function relationships. David moved to the University of Minnesota for graduate studies, where she investigated inhibitor binding to uteroferrin, completing her doctorate in 1990 under the supervision of Lawrence Que Jr. Next, David moved to California Institute of Technology as an National Institutes of Health Postdoctoral Fellow.
Research and career
David worked as an assistant and associate professor in Santa Cruz and Utah before joining the University of California, Davis in 2006. Her research uses the tools of chemical biology to explore the mechanistic details of DNA repair. DNA is damaged by reactive oxygen species (e.g. the hydroxyl radical), and biological organisms have evolved various strategies for regeneration and repair. In particular, she studies the proteins MUTYH and NEIL1, which help to catalyze the repair of damaged DNA as part of the base excision repair pathway. MUTYH is a glycosylase that identifies and cleaves mismatched nucleobases, which triggers DNA repair. David is interested in how MUTYH locates the appropriate damaged target amidst the naturally occurring healthy DNA, as this may have implications in cancer therapeutics and drug discovery.
Awards and honors
American Chemical Society Fellow
American Association for the Advancement of Science Fellow
Alfred P. Sloan Foundation Fellow
Editor of DNA Repair
Environmental Mutagenesis and Genomics Society Education Award
Selected publications
References
Living people
Year of birth missing (living people) St. Olaf College alumni University of Minnesota alumni University of California, Davis faculty 20th-century American chemists 21st-century American chemists American women chemists Fellows of the American Chemical Society Fellows of the American Association for the Advancement of Science