Daniel Boone Hotel is a historic hotel located at Charleston, West Virginia. It is a Classical Revival Style ten story structure with blond brick exterior and tan, modular, stone-looking terra cotta. The building was originally constructed in 1927–29, expanded in 1936 and again in 1949 to provide a total of 465 rooms, a large ballroom and 3 parlor meeting rooms. The overall effect of the facade is to create the common early 20th Century "Skyscraper" look of "Base", two story mezzanine - "Shaft" five stories of 1/1 and 1 story of 6/6 windows - and "Capital" tenth story diamond brick and terra cotta balustrade. The building is "U"-shaped in plan. In the early-1980s the building was extensively renovated to become an office building.
It was listed on the National Register of Historic Places in 1984.