Ripley County Jail, Sheriff's Office and Sheriff's Residence, also known as the Hancock Building, is a historic jail and sheriff's residence located at Doniphan, Ripley County, Missouri. It was built in 1899, and consists of a two-story front section containing the residence, with a one-story rear section containing the sheriff's office and the county jail. The building is constructed of brick, rests on a limestone foundation, and topped by a medium pitched hipped roof. It housed the jail and sheriff's office and residence until 1960.
It was added to the National Register of Historic Places in 1991.