The 1946 United States Senate election in Indiana took place on November 5, 1946. Incumbent Republican U.S. Senator Raymond E. Willis did not run for re-election. Former interim Senator William E. Jenner was elected over Governor of Indiana M. Clifford Townsend.
Republican nomination
Candidates
William E. Jenner, former U.S. Senator (1944–45) and State Senator from Martin County Charles M. La Follette, U.S. Representative from Evansville
Withdrew
Raymond E. Willis, incumbent Senator since 1941 (withdrew at convention)
Convention results
General election
Candidates
William E. Jenner, former interim U.S. Senator (Republican) Elmer G. Johnson (Communist) John Marion Morris (Socialist Labor) M. Clifford Townsend, former Governor of Indiana (Democratic) Elmer D. Riggs (Prohibition)