Edward S. and Mary Annatoile Albert Lilly House is a historic home located at Cape Girardeau, Missouri. It was built in 1897, and is a -story, Colonial Revival style brick dwelling. It has a full-width wraparound front porch with classical columns and porte cochere. It features a medium pitched hipped roof with pediment dormers, ornate pressed metal cornice with dentils and pressed metal window hoods. Also on the property is a contributing -story brick carriage house.
It was listed on the National Register of Historic Places in 2008.