Neumann, experimenting with canaries, found that _Stegomyia fasciata_ could transmit the infection, but less efficiently than species of _Culex_.
The successful cultivation of malarial parasites _in vitro_ was first recorded by C. C. Bass and by Bass and Johns (1912).[206] Since then, J. G. and D. Thomson,[207] and McLellan (1912–13), Ziemann[208] and others have repeated the experiments.
[207] _Annals Trop. Med. and Parasitol._, vi, p. 449; vii, pp. 153, 509.
[208] _Trans. Soc. Trop. Med. and Hyg._, vi, p. 220.
DIFFERENTIAL CHARACTERS OF THE HUMAN MALARIAL PARASITES.
======================================================================= | | |_Laverania malariæ_ Character | _Plasmodium |_Plasmodium vivax_| _Plasmodium | malariæ_ | (Benign tertian) | falciparum_ | (Quartan) | |(Malignant tertian) -------------+------------------+------------------+------------------- Schizogony |Complete in |Complete in forty-|Complete in forty- | seventy-two | eight hours | eight hours | hours | | or less -------------+------------------+------------------+------------------- Trophozoite |Smaller than _P. |Young trophozoite |Young trophozoite | vivax_larger than| large. | small | _L. malariæ_ | | |Pseudopodia not |Long pseudopodia | | marked or long | | -------------+------------------+------------------+------------------- Movements |Rather slow in |Active amœboid |Sometimes actively | immature forms | movements | motile -------------+------------------+------------------+------------------- Pigment |Coarse granules, |Fine granules, |Granules fine and | peripherally | with active | scanty, movement | arranged, little | movement | oscillatory | movement | | -------------+------------------+------------------+------------------- Schizont |Smaller than red |Larger than red |Smaller than red | corpuscle | blood corpuscle | corpuscle -------------+------------------+------------------+------------------- Merozoites |6 to 12 forming |15 to 20 regularly|8 to 32 (according | rosette | arranged | to different | | | authors) arranged | | | irregularly -------------+------------------+------------------+------------------- Gametocytes |Spherical |Spherical |Crescentic -------------+------------------+------------------+------------------- Distribution |About equal number|Larger numbers in |Scanty in periph- of | in peripheral and| visceral blood | eral blood com- parasites in| visceral blood | | pared with the vertebrate | | | enormous numbers host | | | in the internal | | | organs. The latter | | | part of the cycle | | | (schizogony) may | | | occur in the in- | | | ternal organs only -------------+------------------+------------------+------------------- Alterations |Almost normal |Pale and |Corpuscle may be in | | hypertrophied. | shrunken and dark, erythrocytes| |Schüffner’s dots | or may be colour- | | seen in deeply | less. Maurer’s | | stained specimens| coarse dots some- | | | times seen -------------+------------------+------------------+-------------------