As the frontier moved down the Ohio, individual wars were fought and individual treaties were made as occasion offered. At times the tribes yielded readily to white occupation; occasionally they struggled bitterly to save their lands; but the result was always the same. The right bank of the river, long known as the Indian Shore, was contested in a series of wars lasting nearly until 1800, and became available for white colonization only after John Jay had, through his treaty of 1794, removed the British encouragement to the Indians, and General Wayne had administered to them a decisive defeat. Isolated attacks were frequent, but Tecumseh's war of 1811 was the next serious conflict, while, after General Harrison brought this war to an end at Tippecanoe, there was comparative peace along the northwest frontier until the time of Black Hawk and his uprising of 1832.
The left bank of the river was opened with less formal resistance, admitting Kentucky and Tennessee before the Indian Shore was a safe habitation for whites. South of Tennessee lay the great southern confederacies, somewhat out of the line of early western progress, and hence not plunged into struggles until the War of 1812 was over. But as Wayne and Harrison had opened the Northwest, so Jackson cleared the way for white advance into Alabama and Mississippi. By 1821 new states touched the Mississippi River along its whole course between New Orleans and the lead mines of upper Illinois.
In the advance of the frontier to the bend of the Missouri some of the tribes were pushed back, while others were passed and swallowed up by the invading population. Experience showed that the two races could not well live in adjacent lands. The conditions which made for Indian welfare could not be kept up in the neighborhood of white settlements, for the more lawless of the whites were ever ready, through illicit trade, deceit, and worse, to provoke the most dangerous excesses of the savage. The Indian was demoralized, the white became steadily more intolerant.
Although the ingenious Jefferson had anticipated him in the idea, the first positive policy which looked toward giving to the Indian a permanent home and the sort of guardianship which he needed until he could become reconciled to civilized life was the suggestion of President Monroe. At the end of his presidency, Georgia was angrily demanding the removal of the Cherokee from her limits, and was ready to violate law and the Constitution in her desire to accomplish her end. Monroe was prepared to meet the demand. He submitted to Congress, on January 27, 1825, a report from Calhoun, then Secretary of War, upon the numbers of the tribes, the area of their lands, and the area of available destinations for them. He recommended that as rapidly as agreements could be made with them they be removed to country lying westward and northwestward,--to the further limits of the Louisiana Purchase, which lay beyond the line of the western frontier.