Worthen is a surname. Notable people with the surname include:

Amos Henry Worthen, American geologist

Amy Namowitz Worthen (born 1946), American artist

Augusta Harvey Worthen (1823–1910), American author and teacher

Clyde Worthen, American judoka

Ezekiel Worthen (1710–1793), American military officer

Joey Worthen (born 1979), American soccer player

John Worthen (literary critic), English academic, literary critic and biographer

John E. Worthen (born 1933), American university president

Kevin J Worthen (born 1957), American lawyer and BYU president

Molly Worthen (born 1981), American writer

Naz Worthen (born 1966), American football player

Rande Worthen (born 1956), American politician

Sam Worthen (born 1958), American basketball player

Sandra Worthen (1937-2022), American politician

Shawn Worthen (born 1978), American football player

Trebor Worthen (born 1980), American politician

William Ezra Worthen (1819–1897), American civil engineer

Worthen (surname)