The 2021 Women's LEN Super Cup was the 15th edition of the annual trophy organised by LEN and contested by the reigning champions of the two European competitions for Women's water polo clubs. The match was an all-Greek derby between European champions Olympiacos Piraeus of Greece (winners of the 2020–21 LEN Euro League Women) and Kinef Kirishi of Russia (winners of the 2020–21 Women's LEN Trophy). The match was held in Piraeus, Greece, on 17 December 2022.
Olympiacos Piraeus won its second Super Cup, beating Kinef Kirishi 14–11.