U.S. Route 50 (US 50) is a part of the United States Numbered Highway System that runs from West Sacramento, California, to Ocean City, Maryland. In the U.S. state of Indiana, it is part of the state road system. US 50 enters the state in Vincennes. The of US 50 that lie within Indiana serve as a major conduit. All of the highway is listed on the National Highway System. Various sections are rural two-lane highway, urbanized four-lane undivided highway and one-way streets. The easternmost community along the highway is Lawrenceburg at the Ohio state line. US 50 passes through urban areas, farmland and woodland.
Route description
US 50 enters Indiana over the Wabash River and a CSX railroad track as a four-lane, divided highway passing through rural farmland north of Vincennes. The highway heads east, turning southeast, having a cloverleaf interchange with US 41 and US 150. The three routes head southeast; the concurrency ends when US 41 keeps heading south and US 50 and US 150 turn east. The two routes head east towards Washington, as a four-lane divided highway passing through rural farmland. In Wheatland, the highway has an intersection with both SR 550 and SR 241. The road bypasses Washington around the south side of town, intersecting SR 57 and SR 257. On the east side of Washington, the highway has an interchange with Interstate 69 (I–69). After the interchange with I–69, the highway narrows to a two-lane highway and heads east towards Loogootee.
In Loogootee, the highway begins a concurrency with US 231. The concurrency heads north through the downtown area of Loogootee as a two-lane highway, passing commercial and residential properties. The concurrency ends when US 50 and US 150 turn east and with US 231 heading north. The highway heads east from Loogootee towards Shoals; in Shoals US 150 heads southeast towards Paoli and Louisville, Kentucky, and US 50 heads northeast towards Bedford. The highway passes through the Hoosier National Forest and an intersection with SR 650. Southwest of Bedford US 50 begins a concurrency with SR 37. The two routes head north, turning northeast crossing the east folk of the White River. After the river the concurrency turns northwest, then ends at an intersection with SR 450. SR 37 heads north and US 50 heads east, concurrent with SR 450, towards downtown Bedford. The concurrency heads towards downtown Bedford, passing through commercial and residential properties, as a four-lane highway with a center turn lane. Downtown the highway divides into one-way streets at an intersection with M Street, with eastbound on Sixteenth Street and westbound on Fifteenth Street. This intersection is also the eastern terminus of SR 450. The streets head through downtown and have the Lawrence County Court House between them. A block after the court house the one-way streets end at an intersection with H Street. The highway leaves downtown as a two-lane highway passing through mostly residential properties.
US 50 heads east-northeast from Bedford towards Brownstown, passing through farmland and woodland as a two-lane highway. The route has an intersection with SR 446 and SR 235. After SR 235 the road passes through mostly farmland with a few houses. The highway passes through a concurrency with SR 135, before entering Brownstown. In Brownstown the routes have an intersection with SR 250. From Brownstown the route heads northeast towards Seymour, passing through rural farmland with a few houses. US 50 enters Seymour and becomes a four-lane undivided highway, passing through commercial and residential properties, parallel to a CSX Railroad track. In downtown Seymour, the highway becomes a four-lane highway with a center turn lane and it has a short concurrency with SR 11. The route leaves downtown Seymour heading east passing through commercial properties and having an interchange with I–65 (coincidentally also numbered Exit 50). East of the interchange the road has an intersection with US 31 and the roadway narrows to a two-lane highway.