In 1527, he returned to Basel, where he was appointed town physician. It was a characteristic of his independence and of his mind, method and design, that he lectured in the language of the place, German, foregoing the Latin tongue, usual up to that time for such teaching. He did not shrink from a bold criticism of the medical ideas and methods then current. The effect of this independence and teaching was that for a couple of years his reputation and his practice increased wonderfully. But the time thus passed allowed his enemies not only to see the danger for them that lay ahead, but to take such action as they could to obviate it. Reactionary forces are generally--if not always--self-protective, without regard to the right or wrong of the matter, and Paracelsus began to find that the self-interest and ignorance of the many were too strong for him, and that their unscrupulous attacks began to injure his work seriously. He was called conjurer, necromancer, and many such terms of obloquy. Then what we may call his “professional” enemies felt themselves strong enough to join in the attack. As he had kept a careful eye on the purity of medicines in use, the apothecaries, who, in those days worked in a smaller field than now, and who found their commerce more productive through guile than excellence, became almost declared opponents. Eventually he had to leave Basel. He went to Esslingen, from which however he had to retire at no distant period from sheer want.
Then began a period of wandering which really lasted for the last dozen years of his life. This time was mainly one of learning in many ways of many things. The ground he covered must have been immense, for he visited Colmar, Nurnberg, Appengall, Zurich, Augsburg, Middelheim, and travelled in Prussia, Austria, Hungary, Egypt, Turkey, Russia, Tartary, Italy, the Low Countries and Denmark. In Germany and Hungary he had a bad time, being driven to supply even the bare necessaries of life by odd--any--means, even to availing himself of the credulity of others--casting nativities, telling fortunes, prescribing remedies for animals of the farm such as cows and pigs, and recovering stolen property; such a life indeed as was the lot of a mediæval “tramp.” On the other hand, as a contra he did worthy work as a military surgeon in Italy, the Low Countries and Denmark. When he got tired of his wandering life, he settled down in Salsburg, in 1541, under the care and protection of the Archbishop Ernst. But he did not long survive the prospect of rest; he died later in the same year. The cause of his death is not known with any certainty, but we can guess that he had clamorous enemies as well as strong upholding from the conflicting causes given. Some said that he died from the effects of a protracted debauch, others that he was murdered by physicians and apothecaries, or their agents, who had thrown him over a cliff. In proof of this story it was said that the surgeons had found a flaw or fracture in his skull which must have been produced during life.