Maria Mikhaĭlovna Manàsseina, also known as Marie de Manacéïne, was born in Korkunova in 1841 and died in Saint Petersburg on 17 March in 1903. She was buried at the Novodévitxi cemetery. Manàsseina was the daughter of Mikhaïl Korkunov, a historian; her brother Nikolai Korkunov was a philosopher. She was the disciple of the professor Ivan Tarkhànov.
Manàsseina was one of the first women in the Russian Empire to graduate in medicine. First, she received a special certification authorizing her as a “female doctor” and, later, the official Medicine degree certification. She is nowadays considered an expert neuroscientist in the field of physiological chemistry and a pioneer in somnology (the study of sleep or sleep science) and biochemistry. She published numerous articles in French, Russian, and German under different names: Marie de Manacéïne, Maria Manàsseina, or Marie von Manassein. She was not uncommonly referred to as a male doctor. Despite her outstanding contributions, in the last ten years, her name has not been cited more than 100 times.
Personal life
While still a student, Manàsseina married Poniatovsky, another student, whose first name is unknown. They participated alongside in the Narodniki revolutionary circles, which were groups of Russian revolutionaries that appeared during 1860–70 to actively oppose and protest against the tsar, the Russian emperor, which was not overthrown until the Russian Revolution in 1917. The Narodniki movement was a kind of socialism built upon economically autonomous entities; several towns were united to create a kind of federation to substitute the state.
However she was considered very conservative as an adult She provided the ministry of Education with research and information on how to control and suppress student protests and revolutionary activity. Moreover, she publicly expressed her loyalty to the tsarist government, for which she received generous amounts of money.
Considering these contradictions in her biography, one can believe that Manàsseina opted for a more conservative ideology over the years. However, it is not unreasonable to think —taking into account the difficulties faced by women to establish themselves in the scientific and academic world— that Manàsseina publicly conformed to the ideologies of the government to receive financial support and continue her career.
Poniatovsky, her first husband, was arrested and he died during political exile. In 1856, she married Vyacheslav Avksentievich Manassein, a renowned man in the field of medicine in Russia.
Contributions to Science
Neuroscience
Manàsseina’s most distinguished contribution in the field of neuroscience was her research on sleep deprivation. She was one of the first scientists to state that while we sleep the brain is active.
To conduct this investigation, she worked alongside professor Ivan Romanovich Tarkhanov, who was also interested in sleep disorders. They put ten puppies (two to four months old) under a state of permanent insomnia by keeping them constantly active. These puppies had previously been fed and well taken care of. The sleep deprivation was fatal after four to five days, leading to the death of all the puppies. As a control measure, they deprived other puppies of food. Even though they had been starving for 20–25 days, they could be rescued and returned to a healthy condition. These results clearly showed the importance of sleeping for life to be maintained and that sleep deprivation leads to a faster death than the deprivation of nutrients. Further research showed that the effects of sleep deprivation in the puppies included a body temperature decrease of , a reduction of the number of red blood cells, local brain hemorrhages, cerebral ganglion impairment, etc.
As a consequence of this research, Manàsseina concluded that sleeping is as necessary as nutrition for the regeneration of the brain cells. She also emphasized the idea that, during sleep, there is in the brain. This assertion challenged the prevailing belief at that time that sleeping was merely a passive state of the organism. She also stressed that only the brain structures involved in maintaining consciousness are inactive during sleep–thus, sleeping means resting the consciousness. This intuition is remarkable considering that the electroencephalogram didn't yet exist.
Her work had a great impact on the scientific community and many scientists replicated her model: