Middleton's Plantation, also known as Chisolm's Plantation and The Launch, is a historic plantation house located near Edisto Island, Charleston County, South Carolina. It was built about 1830, and is a two-story wooden house, with one-room wings. It sits on a raised arcaded brick basement. It features a small Tuscan order colonnaded porch on the land side facade and a recessed, full width, Tuscan order colonnaded porch on the water side. It was the home of Oliver Hering Middleton, son of Governor Henry Middleton of Middleton Place.
It was listed on the National Register of Historic Places in 1971.