Thus, one may see that Ferdinand judged Alexander VI with his usual perspicacity; this, however, did not hinder him, as we shall soon perceive, from being the first to contract an alliance with him.
The duchy of Milan belonged nominally to John Galeazzo, grandson of Francesco Sforza, who had seized it by violence on the 26th of February, 1450, and bequeathed it to his son, Galeazzo Maria, father of the young prince now reigning; we say nominally, because the real master of the Milanese was at this period not the legitimate heir who was supposed to possess it, but his uncle Ludovico, surnamed 'il Moro', because of the mulberry tree which he bore in his arms. After being exiled with his two brothers, Philip who died of poison in 1479, and Ascanio who became the cardinal, he returned to Milan some days after the assassination of Galeazzo Maria, which took place on the 26th of December 1476, in St. Stephen's Church, and assumed the regency for the young duke, who at that time was only eight years old. From now onward, even after his nephew had reached the age of two-and-twenty, Ludovico continued to rule, and according to all probabilities was destined to rule a long time yet; for, some days after the poor young man had shown a desire to take the reins himself, he had fallen sick, and it was said, and not in a whisper, that he had taken one of those slow but mortal poisons of which princes made so frequent a use at this period, that, even when a malady was natural, a cause was always sought connected with some great man's interests. However it may have been, Ludovico had relegated his nephew, now too weak to busy himself henceforward with the affairs of his duchy, to the castle of Pavia, where he lay and languished under the eyes of his wife Isabella, daughter of King Ferdinand of Naples.
As to Ludovico, he was an ambitious man, full of courage and astuteness, familiar with the sword and with poison, which he used alternately, according to the occasion, without feeling any repugnance or any predilection for either of them; but quite decided to be his nephew's heir whether he died or lived.
Florence, although she had preserved the name of a republic, had little by little lost all her liberties, and belonged in fact, if not by right, to Piero dei Medici, to whom she had been bequeathed as a paternal legacy by Lorenzo, as we have seen, at the risk of his soul's salvation.