_Experiment No. 1._--On May 31, 1906, a sheep weighing 32.2 kilos was fed with a concentrated aqueous extract of 1,000 grams of the fresh _Astragalus mollissimus_ preserved in chloroform water. The temperature at 11 o'clock, the time of feeding, was 103.4°F. At 11.45 a.m. this dose was repeated. At 12 o'clock the temperature was 104.1°F. At 12.45 the animal urinated. At 1.10 p.m. a similar extract of 2,000 grams was fed. The total liquid used was 1,500 c.c. On June 1 no symptoms were noted. On June 5 an extract of 3,000 grams of fresh _Aragallus lamberti_ and 3,000 grams of _Astragalus mollissimus_ was fed. After feeding this the animal could be easily turned over on its back and its ear pricked with impunity. The animal at this time weighed 30.8 kilos. On June 6, at 11 a.m., the temperature was 104°F. The sheep had numerous soft stools, and was very dull, and would not eat. On June 7 the temperature was 103.7°F. and the sheep still refused to eat. On the 8th the temperature was 103.2°F. at 10.40 a.m., and the stools were still numerous and soft.
There were then fed 640 c.c., representing the aqueous extract of 4,000 grams of the fresh _Aragallus lamberti_. The animal could be easily turned on its back. It weighed at this time 28.57 kilos. On June 9, at 10.47 a.m., the temperature was 103.4°F. The sheep still did not eat, but had no diarrhea. It now weighed 27.9 kilos, and the temperature was 103°F. at 10.45 a.m.
On June 13 the animal began to eat, and 1,700 c.c. of fluid, representing 5,500 grams of the fresh _Aragallus lamberti_, were fed. The temperature at 12.30 p.m. was 103°F. On June 14 the temperature was 103.4°F., the animal weighed 28.3 kilos, and refused food. On June 16 the weight was 28.3 kilos; the temperature at 2 p.m. was 103.5°F. There was no diarrhea.
On June 19 the aqueous extract of 1,000 grams of the dried _Astragalus mollissimus_ was fed with 420 c.c. of water. The temperature was 102.6° F. On June 20 the temperature was 102.9°F. at 10.45 a.m.
On June 21 500 c.c., representing the aqueous extract of 1,000 grams of the dried _Astragalus mollissimus_, were again fed. The animal now weighed 26.9 kilos. On June 26 the animal weighed 26 kilos, and its gait was very uncertain. The temperature was 104.2°F. It was fed 300 c.c. of fluid, representing the extract of 400 grams of the dried _Astragalus mollissimus_. On June 29 the animal weighed 26.8 kilos and the temperature was 102.8°F. It was fed the extract of 1,000 grams of dried _Astragalus mollissimus_ in 500 c.c. of water. On June 30, at 10.45 a. m., the temperature was 104.2°F. The animal was very dull and died at night.