Hostilities between Israel and Syria lasted to the days of Ahab. From Omri the king of Syria took cities and the right to establish a quarter for his merchants in Samaria (1 Kings xx. 34). His son Ben-Hadad made an unsuccessful attack on Israel at Aphek, and was allowed by Ahab to depart on a reversal of these terms (loc. cit.). This was the cause of a prophetic denunciation (1 Kings xx. 42). According to the Assyrian records Ahab fought as Ben-Hadad's ally at the battle of Karkar against Shalmaneser in 854. This seems to indicate an intermediate defeat and vassalage of Ahab, of which no direct record remains; and it was probably in the attempt to throw off this vassalage in 853, the year after the battle of Karkar, that Ahab met his death in battle with the Syrians (1 Kings xxii. 34-40). In the reign of Jehoram, Naaman, the Syrian general, came and was cleansed by the prophet Elisha of leprosy (2 Kings v.).
In 843 Hazael assassinated Ben-Hadad and made himself king of Damascus. The states which Ben-Hadad had brought together into a coalition against the advancing power of Assyria all revolted; and Shalmaneser, king of Assyria, took advantage of this in 842 and attacked Syria. He wasted the country, but could not take the capital. Jehu, king of Israel, paid tribute to Assyria, for which Hazael afterwards revenged himself, during the time when Shalmaneser was distracted by his Armenian wars, by attacking the borders of Israel (2 Kings x. 32).
Adad-nirari IV. invaded Syria and besieged Damascus in 806. Taking advantage of this and similar succeeding events, Jehoash, king of Israel, recovered the cities that his father had lost to Hazael.
In 734 Ahaz became king of Judah, and Rezon (Rasun, Rezin), the king of Damascus at the time, came up against him; at the same time the Edomites and the Philistines revolted. Ahaz appealed to Tiglath-Pileser III., king of Assyria, sent him gifts, and besought his protection. Tiglath-Pileser invaded Syria, and in 732 succeeded in reducing Damascus (see also BABYLONIA AND ASSYRIA, _Chronology_, § 5, and JEWS, §§ 10 sqq.).
Except for the abortive rising under Sargon in 720, we hear nothing more of Damascus for a long period. In 333 B.C., after the battle of Issus, it was delivered over by treachery to Parmenio, the general of Alexander the Great; the harem and treasures of Darius had here been lodged. It had a chequered history during the wars of the successors of Alexander, being occasionally in Egyptian hands. In 112 B.C. the empire of Syria was divided by Antiochus Grypus and Antiochus Cyzicenus; the city of Damascus fell to the share of the latter. Hyrcanus took advantage of the disputes of these rulers to advance his own kingdom. Demetrius Eucaerus, successor of Cyzicenus, invaded Palestine in 88 B.C., and defeated Alexander Jannaeus at Shechem. On his dethronement and captivity by the Parthians, Antiochus Dionysus, his brother, succeeded him, but was slain in battle by Haritha (Aretas) the Arab--the first instance of Arab interference with Damascene politics. Haritha yielded to Tigranes, king of Armenia, who in his turn was driven out by Q. Caecilius Metellus (son of Scipio Nasica), the Roman general. In 63 Syria was made a Roman province.