Man with the Screaming Brain is a 2005 science fiction/slapstick film co-written, produced, directed, and starring Bruce Campbell. It is Campbell's feature film directorial debut. The film was co-written by David Goodman and co-stars Ted Raimi.

Plot

Bruce Campbell plays William Cole, the wealthy CEO of a U.S. drug company who travels to Bulgaria with his wife, Jackie in the hopes of diversifying his company's financial interests. Cole is a stereotypical ugly American who constantly complains about the lack of Americanization of the former communist country. They're driven to a hotel by a taxi driver, and former KGB agent, named Yegor Stragov, in which Yegor gives William a ring to give to Jackie. While William is at the construction of a subway, Jackie secretly cheats on William with Yegor.

Man with the Screaming Brain

William gets back to the hotel and bumps into the hotel maid and gypsy, Tatoya, who kills men that date and dump her. Jackie then comes in, catches William kissing Tatoya and dumps him. William chases Tatoya, who had taken William's money and ring (which is revealed to be Tatoya's that she gave to Yegor when they dated), and Tatoya knocks him in the head with a pipe outside the hotel. Yegor witnesses this and so Tatoya kills Yegor with his own gun.

Man with the Screaming Brain

A vengeful Jackie has William’s life support plug pulled in hospital, and then goes to Gypsy Town where Tatoya lives and attempts to kill her, only to have Tatoya kill her by throwing her down a flight of stairs. Meanwhile, a still alive William wakes up in the warehouse of a Russian scientist named Dr. Ivan Ivanovich Ivanov, and his idiotic assistant Pavel, who had removed the damaged parts of William's brain and replaced it with healthy tissue from Yegor's. When William runs out of the warehouse, he discovers he can hear Yegor's voice in his head; together they both plan to "get the woman that killed us both". Jackie, who had also been picked up by Dr. Ivanov and Pavel, has her brain put inside a robot; and so she escapes and also plans to exact revenge on Tatoya.

Man with the Screaming Brain

William/Yegor and Robo-Jackie chase Tatoya around town. William gets involved in a car crash with his foot underneath a car and Tatoya makes another attempt to kill William by setting the leaking car gasoline alight. Jackie saves him and is presumed dead in the explosion. After avoiding some bar punks that believe William "raped Tatoya on her wedding day", William/Yegor begin suffering brain damage due to their cells not able to coexist in the same head. Jackie, who had survived the explosion, appears and attempts to kill Tatoya by throwing her off a bridge; until Tatoya stabs Jackie's brain, causing her to malfunction, and has Jackie thrown off the bridge. William chases Tatoya through the subway construction and the sewer and finally kills Tatoya by dropping her in sewer river, but not before taking back the ring. William and Jackie then confess their love for each other before Jackie's batteries finally die, as does William due to the brain cells of him and Yegor wearing out. Pavel brings William, Jackie and Tatoya's body back to Dr. Ivanov to fix them; as he had earlier found a way to make William and Yegor's brain cells coexist in the same head.

The movie ends with William back in the U.S. six months later, still sharing his body with Yegor's brain now completely synched and stabilized. He goes to a brain trauma benefit with Jackie, whose brain had been transferred into Tatoya's body.

Cast

Bruce Campbell as William Cole

Tamara Gorski as Tatoya

Ted Raimi as Pavel

Antoinette Byron as Jackie Cole

Stacy Keach as Dr. Ivan Ivanovich Ivanov

Vladimir Kolev as Yegor Stragov

Valentine Glasbeily as Uri

Velizar Binev as The Mayor

Raicho Vasilev as The Bartender

Jonas Talkington as Larry

Mihail Elanov as Punk #1

Neda Sokolovska as The Waitress

Remington Franklin as Bar Punk

Todor Nikolov as Doctor (uncredited) Yuri Safchev as Tatoya's Father (uncredited)

Production

The Man with the Screaming Brain was originally supposed to take place in East L.A., but it was shot in Bulgaria instead, in order to save production costs. Campbell persuaded Syfy to let him rewrite the script so that it would be set in Bulgaria, instead of trying to make Bulgaria look like East L.A., which saved the production further money.