Arroyo Seco is a tributary stream to Schell Creek in southern Sonoma County, California, United States. In Spanish arroyo seco means "dry creek".
Arroyo Seco Creek drains a portion of the western slopes of the southern Mayacamas Mountains. Its watershed, along with the entire Mayacamas mountain block, was formed in the Miocene era by volcanic action and with tectonic uplift about 12 million years ago.
Soils of the immediate streambed and its vicinity are classified as the riverwash series, recent deposition of sands and gravels.
Arroyo Seco Creek springs near the Napa County line about northeast of Sonoma, California. It flows southward, emerging from near Sonoma Valley Hospital. After a confluence with Haraszthy Creek, it crosses under State Route 12 near Schellville, California, where it flows into Schell Creek. Schell Creek discharges to a network of sloughs that eventually empty into Sonoma Creek, which in turn empties into the Napa Sonoma Marsh and San Pablo Bay.